Long QT syndrome (in you or a family member) To make sure Invega Sustenna is safe for you, tell your doctor if you have ever had: The longer you use Invega Sustenna, the more likely you are to develop this disorder, especially if you are a woman or an older adult.īefore you receive your first injection, tell your doctor if you have never taken oral (by mouth) Invega Sustenna or risperidone. High doses or long-term use of paliperidone can cause a serious movement disorder that may not be reversible. Invega Sustenna may increase the risk of death in older adults with dementia-related psychosis and is not approved for this use. You should not use Invega Sustenna if you are allergic to Invega Sustenna or to risperidone ( Risperdal). Call your doctor right away if you have signs of infection like fever, chills, or sore throat. Tell your doctor if you have ever had a low white blood cell count. This may lead to a higher chance of infection. Low white blood cell counts have happened with drugs like this one. Call your doctor right away if you have trouble controlling body movements or problems with your tongue, face, mouth, or jaw like tongue sticking out, puffing cheeks, mouth puckering, or chewing. The risk is greater with longer use or higher doses, but it may also occur after short-term use with low doses. The risk is greater with diabetes and in older adults, especially older women. This problem may lessen or go away after stopping Invega Sustenna, but it may not go away. Some people may get a severe muscle problem called tardive dyskinesia. To lower the chance of feeling dizzy or passing out, rise slowly if you have been sitting or lying down. This may lead to falling, which can cause broken bones or other health problems.
Invega Sustenna is not approved for use in older adults with dementia-related psychosis.ĭizziness, sleepiness, and feeling less stable may happen with Invega Sustenna. After that you will only need to get one injection each month.
When you receive your first dose of Invega Sustenna you will need to get a second dose one week later. Invega Sustenna is also used alone or with other medicines to treat schizoaffective disorder in adults. Invega Sustenna is prescription medicine used to treat schizophrenia in adults. Invega Sustenna ( paliperidone) is an extended-release antipsychotic medicine given by intramuscular injection. Medically reviewed by Philip Thornton, DipPharm. Jennifer Robinson, a cardiologist at the University of Iowa, who led the study.Generic name: paliperidone (injection) (PAL ee PER i DONE) “To have this result emerge so quickly in this study is very encouraging,” said Dr. The 2,341-patient study, called Odyssey Long Term, is expected to conclude early next year, but researchers said the early sign of effectiveness was clearly positive. Among the alirocumab group, 1.4 percent of patients suffered a major cardiovascular event compared with 3.0 percent of those in the placebo group. The encouraging cardiovascular findings came from an interim safety analysis of one of these studies showing patients on alirocumab were less prone to a combination of cardiovascular events, including cardiac death, heart attack, stroke and chest pain requiring hospitalization.īoth groups of patients received conventional anti-cholesterol statin pills in addition to alirocumab or a placebo.
But details from four of those trials have only now been reported at the European Society of Cardiology’s annual meeting in Barcelona. Sanofi and Regeneron said in July that nine studies had shown consistent LDL reductions with alirocumab, which is injectable.